Starting the Grignard reaction

The Solvent Effects on Grignard Reaction

This research focuses on the effects of water in a solvent on a synthetic process of a Grignard reagent which is common in organic synthesis and triggered an accident in Japan. For the measurement, a hermetically sealed apparatus was prepared to fit a small-scaled reaction calorimeter. The experimental results revealed that the induction period appeared as the water content in the solvent incre...

High-Yield Alkylation and Arylation of Graphene via Grignard Reaction with Fluorographene

C functionalization of graphene significantly broadens its application potential via tuning its electronic and surface properties. Therefore, a wide range of dry and wet chemistry approaches have been developed for graphene functionalization. Despite recent progress in this field, covalent modification of graphene is still hampered by its low reactivity. Moreover, the reactivity depends on the ...

Facile Synthesis of End-Functionalized Regioregular Poly(3-alkylthiophene)s via Modified Grignard Metathesis Reaction

A simple method for the synthesis of end-functionalized regioregular poly(3-alkylthiophene)s is presented. Using a modified Grignard metathesis (GRIM) reaction, a series of polymers have been synthesized bearing functional groups on one or both ends of the polymer. This method has been demonstrated to work with a variety of different types of Grignard reagents (i.e., aryl, alkyl, allyl, vinyl, ...

Single electron transfer-induced cross-coupling reaction of alkenyl halides with aryl Grignard reagents.

Alkenyl halides were found to undergo coupling with aryl Grignard reagents to give the corresponding styrene derivatives in a stereo-retained manner. The cross-coupling reaction is considered to proceed through a single electron transfer mechanism.

Reaction Between Grignard Reagents and Heterocyclic N-oxides Synthesis of Substituted Pyridines, Piperidines and Piperazines